News International Sugar Journal

Targeted proteomics for metabolic pathway optimization to facilitate biobased chemicals production [Registered]

Efforts to engineer new metabolic pathways into microbes for the production of valuable chemical products, such as biofuels or therapeutic drugs, received a significant boost following a successful demonstration of new technique by scientists at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI). The technique, which researchers call “targeted proteomics” speeds up and improves the ability to identify and quantify specific proteins within a cell or microorganism. This research is described in the journal Metabolic Engineering (2011, 13 (2): 194-203). Christopher Petzold, chemist and deputy director for proteomics at JBEI, who led this research notes that metabolic engineers…

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