International Sugar Journal

Metabolic engineering of yeast with Crispr Cas 12a paves way for improved production of biobased products [Full subscriber]

Researchers from DSM’s Rosalind Franklin Biotechnology Center in Delft, the Netherlands, and the University of Bristol have shown how to unlock CRISPR’s potential for regulating many genes simultaneously, thereby opening the door to more efficient and sustainable production of biobased products.

Read more …

Engineered bacteria produce super-strong spider silk [Full subscriber]

Researchers at Washington University, US, have engineered bacteria that can make fibres that are stronger and tougher than some natural spider silks.

Read more …

Engineered yeast converts toxin aldehydes from hydrolysed lignocellulosic feedstock into alcohol [Full subscriber]

In the production of cellulosic biofuels, breaking down lignocellulosic feedstock to produce fermentable sugars releases numerous by-products that are toxic to yeast most commonly used to produce biofuels. Researchers at the Massachusetts Institute of Technology have engineered yeast to convert toxic cellulosic by-product aldehydes into alcohols.

Read more …

Engineering bacteria as “cell-factories” with a genetic switch to produce high-value chemicals [Full subscriber]

Researchers at the University of Warwick (UoW) have engineered bacteria with an irreversible genetic switch that reroutes their chemistry to produce high-value chemicals.

Read more …

Conagen scales up production of biobased capsaicinoid compounds [Full subscriber]

The biotech start-up Conagen recently announced it has successfully scaled up its fermentation process for the production of premium capsaicin and its related capsaicinoid molecules such as dihydrocapsaicin and nonivamide, a capsaicinoid used in topical muscle pain relievers and in synthetic pepper spray.

Read more …

Pseudomonas putida metabolically engineered to produce itaconic acid from lignocellulosic feedstock [Full subscriber]

Researchers at the Oak Ridge National Laboratory (ORNL), USA have successfully bioengineered a microbe to efficiently turn lignocellulosic feedstock into itaconic acid, an industrial chemical used in plastics and paints.

Read more …

E. coli engineered to synthesise chondroitin sulfate [Full subscriber]

Sulfated glycosaminoglycans (GAGs) are a class of important biologics that are currently manufactured by extraction from animal tissues. Although such methods are unsustainable and prone to contamination, animal-free production methods have not emerged as competitive alternatives due to complexities in scale-up, the requirement for multiple stages and the cost of co-factors and purification. Now, researchers at the Rensselaer Polytechnic Institute, US have developed one-step biosynthesis of chondroitin sulfate (CS), a type of GAG, a polysaccharide molecule used in pharmaceuticals and nutraceuticals, via reprogrammed E. coli.

Read more …

Light-dependent enzyme promotes drop-in fuels production from cellulosic feedstock [Full subscriber]

Using an unusual, light-dependent enzyme and a newly discovered enzymatic mechanism, researchers from Aarhus University, Denmark and Massachusetts Institute of Technology have succeeded in producing drop-in fuel from lignocellulosic feedstock.

Read more …

Engineered Corynebacterium glutamicum produces high yield of glutaric acid [Registered]

Researchers at the Korean Advanced Institute of Science and Technology (KAIST) have engineered Corynebacterium glutamicum strain capable of producing a high yield of the platform chemical glutaric acid without by-products from glucose.

Read more …

Yeast metabolically engineered to synthesis triterpenoid saponins [Full subscriber]

Researchers at Osaka University, in collaboration with the National Agriculture and Food Research Organization (NARO), RIKEN, and Chiba University have discovered a vital link in the complex biochemical pathway for saponin synthesis. Their discovery paves the way for improving the commercial production of these high-value products.

Read more …