Using an unusual, light-dependent enzyme and a newly discovered enzymatic mechanism, researchers from Aarhus University, Denmark and Massachusetts Institute of Technology have succeeded in producing drop-in fuel from lignocellulosic feedstock.
Researchers at the Korean Advanced Institute of Science and Technology (KAIST) have engineered Corynebacterium glutamicum strain capable of producing a high yield of the platform chemical glutaric acid without by-products from glucose.
Researchers at Osaka University, in collaboration with the National Agriculture and Food Research Organization (NARO), RIKEN, and Chiba University have discovered a vital link in the complex biochemical pathway for saponin synthesis. Their discovery paves the way for improving the commercial production of these high-value products.
Synthetic biology allows us to bioengineer cells to synthesize novel valuable molecules such as renewable biofuels or anticancer drugs. However, traditional synthetic biology approaches involve ad-hoc engineering practices, which lead to long development times. Now, researchers at the Department of Energy’s Lawrence Berkeley National Laboratory have created a new tool that adapts machine learning algorithms to the needs of synthetic biology, dramatically reducing the time spent engineering drugs and chemicals.
Plants can produce a wide range of molecules, many of which help them fight off harmful pests and pathogens. Biologists have harnessed this ability to produce many molecules important for human health — aspirin and the antimalarial drug artemisinin, for example, are derived from plants. Now, researchers at the Joint BioEnergy Institute (JBEI) and Stanford University have designed and engineered new synthetic metabolic pathways to create new-to-nature biopesticides with novel anti-fungal activity.
Researchers at Stanford University report the first successful microbial biosynthesis of the tropane alkaloids hyoscyamine and scopolamine, a class of neuromuscular blockers naturally found in plants in the nightshade family.
Researchers at the University of Edinburgh have engineered E. coli to produce the platform chemical adipic acid used in nylon manufacturing.
researchers at Kobe University, Japan have developed .a new strategy called Parallel Metabolic Pathway Engineering (PMPE), allowing them to fully exploit both sugars for target chemical production and microbe propagation. They used this approach to alter E. coli bacteria in order to successfully boost the production of the nylon precursor muconic acid.
Researchers at the Weizmann Institute of Science in Israel have engineered Escherichia coli that consume just CO2 as their nutrient source, instead of organic compounds. This breakthrough could provide a foundation for harnessing synthetic biology to develop carbon-neutral bioproduction processes for food and fuels.
Researchers at Kobe University’s Engineering Biology Research Centre have succeeded in synthesizing astaxanthin using the fast-growing marine cyanobacterium Synechococcus sp. PCC7002.