News International Sugar Journal

Synthetic chromosomes in yeast advanced by synthetic biology [Registered]

Recent advances in DNA synthesis technology have enabled the construction of novel genetic pathways and genomic elements, furthering our understanding of system-level phenomena. The ability to synthesize large segments of DNA allows the engineering of pathways and genomes according to arbitrary sets of design principles. Researchers at John Hopkins University have replaced all of the DNA in the arm of a yeast Saccharomyces cerevisiae chromosome with computer-designed, synthetically produced DNA that is structurally distinct from its original DNA to produce a healthy yeast cell. These results confirm that large pieces of DNA can be synthesized and inserted into a chromosome,…

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