News International Sugar Journal

Reversing E. coli’s metabolism speeds up butanol production [Registered]

Rice University engineering researchers reversed the metabolism of bioengineered Escherichia coli to rapidly convert glucose into butanol. The researchers reversed one of the most efficient of all metabolic pathways — the beta oxidation cycle — to speed up butanol production. The research, led by Ramon Gonzalez was published online in Nature (on 10 August 2011). On a cell-per-cell basis, the bacteria produced the butanol, about 10 times faster than any previously reported organism. One of the major obstacles to biobutanol production is that microbes used to produce butanol do not tolerate it well so produce only small quantities. Whereas you…

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