News International Sugar Journal

Korean researchers engineer Escherichia coli to produce platform chemicals [Registered]

5-aminovalic acid (5AVA) is the precursor of valerolactam, a potential building block for producing nylon 5, and can potentially be used as a C5 platform chemical for synthesizing 5-hydroxyvaleric acid, glutaric acid, and 1,5-pentanediol. It has been reported that a small amount of 5AVA is accumulated in Pseudomonas putida that has impaired L-lysine catabolism since 5AVA is a natural metabolite of L-lysine catabolism in P. putida. However, direct fermentative production of 5AVA has not yet been demonstrated, which might have great potential to open market for C5 chemicals and plastics. In the paper published in Metabolic Engineering, a Korean research…

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