News International Sugar Journal

Breakthrough in regulating build-up of toxic metabolites in microbes engineered to produce specific chemicals [Registered]

The first dynamic regulatory system that prevents the build-up of toxic metabolites in engineered microbes has been reported by a team of researchers with the US Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI). The researchers used their system to double the production in Escherichia coli of amorphadiene, a precursor to the premier antimalarial drug artemisinin. Using genome-wide transcriptional analysis, the JBEI researchers identified native regions of DNA – called “promoters” – in E. coli that respond to toxic metabolites by promoting the expression of protective genes. They then developed a system based on these promoters for regulating artificial metabolic…

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